doc. PharmDr. Magdaléna Šustková, CSc.












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            Department of Pharmacology 3FM CU
            https://www.lf3.cuni.cz/3LF-400.html [ URL "https://www.lf3.cuni.cz/3LF-400.html"]


            Topic title
            New pharmacological approaches in addiction treatment based on neuronal cooperations in th
            system.





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            * Description of scientific activity

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            Assoc. Prof. Šustková graduated from the Faculty of Pharmacy of Charles University in Hrad
            in clinical pharmacy and completed her doctoral studies at the former Research Institute f

            and Biochemistry in Prague. Now she works as an assistant professor and researcher at the 
            Pharmacology, 3rd Medical Faculty of Charles University and elsewhere. She has long been i
            the field of substance abuse and addiction. She successfully defended her habilitation the

            "Ghrelin/GHS-R1A antagonism in the mechanisms of opioid and methamphetamine addiction" in 
            medical pharmacology at the 1st Faculty of Medicine. She has completed a number of interna
            and internships. In neuropsychopharmacological experimental research, the department uses 

            sophisticated models of addiction (including intravenous self-administration, in vivo micr




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            * Selected publications

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            Charalambous C., Havlickova T., Lapka M., Puskina N., Slamberova R., Kuchar M., Sustkova-F
            M.: Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and

            Stimulation Influenced by Ghrelin Receptor Antagonism in Rats. Int J Mol Sci. 2021 Feb 27;
            10.3390/ijms22052397
            IF časopisu: IF 5,923/2021); Kvartil v oboru: Q1 (Biochemistry & Molecular Biology)


            Charalambous, C.; Lapka, M.; Havlickova, T.; Syslova, K.; Sustkova-Fiserova, M.: Alteratio
            Accumbens Dopamine, Endocannabinoids and GABA Content During WIN55,212-2 Treatment: The Ro

            Int. J. Mol. Sci. 2021, 22, 210.
            doi.org/10.3390/ijms22010210
            IF časopisu: IF 5,923/2020; Kvartil v oboru: Q1 (Biochemistry & Molecular Biology)


            Sustkova-Fiserova, M.; Pushkina, N.; Havlickova, T.; Lapka, M.; Syslova, K.; Pohorala, V.;
            C.: Ghrelin receptor antagonism of fentanyl-induced conditioned place preference, intraven

            administration and dopamine release in the nucleus accumbens in rats. Addiction Biology, 2
            e12845. DOI: 10.1111/adb.12845.
            IF: 4.280/2020, Kvartil v oboru: Q1/2020 (Substance Abuse)





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            * Selected or ongoing grants/clinical studies
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            GAČR 21-30795S Modulation of central ghrelin signalling - a new hope for the treatment of 
            dependence


            GAČR 14-03708S Determination of the critical developmental period for the effects of metha
            laboratory rat


            IGA NT/13687-3/2012 The role of appetite-affecting peptide hormones in opioid and alcohol 



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            * PhD Students
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            Number of PhD students currently studying: 5 (3 of them will finish the studies in 2022)
            Number of defended students with year of defence: 2 (2021; 2018)