MUDr. Adéla Krajčová, Ph.D. ****************************************************************************************** * ******************************************************************************************
Department of Anaesthesia and Intensive Care Medicine 3FM CU and UHKV / Oxylab https://www.lf3.cuni.cz/3LF-776.html [ URL "https://www.lf3.cuni.cz/3LF-776.html"] https://www.kar3lf.cz/en/research-2/ [ URL "https://www.kar3lf.cz/en/research-2/"] Topic title Pathophysiology of intensive care acquired muscle weakness - the role of mitochondrial dys *========================================================================================= * Description of scientific activity *========================================================================================= The focus of our research group is to study altered mitochondrial biology of human tissues muscle) in critically ill patients influenced either by severe illness itself (sepsis, ICU weakness) or e. g. drug administration. We use tools and methods to study both mitochondri and morphology (high resolution respirometry, extracellular flux analysis, techniques base microscopy etc.). Our group also works on joint scientific projects with researchers from in the UK, Norway and France. We currently plan to open a PhD position which will be focus care unit-acquired muscle weakness, which is a common complication following critical illn identify if critical illness induces alteration of mitochondrial function and structure in that could later impair skeletal muscle recovery. In this project, PhD student will study metabolism and dynamics of satellite cells isolated from human skeletal muscle of critical The ideal candidate should have a background in either natural sciences or medicine. *========================================================================================= * Selected publications *========================================================================================= Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pok PLoS One. 2020 Jan 15;15(1):e0226142. Krajčová A, L?vsletten NG, Waldauf P, Frič V, Elkalaf M, Urban T, Anděl M, Trnka J, Thores F. Effects of Propofol on Cellular Bioenergetics in Human Skeletal Muscle Cells. Crit Care Mar;46(3):e206-e212. Krajčová A, Waldauf P, Anděl M, Duška F. Propofol infusion syndrome: a structured review o studies and 153 published case reports. Critical Care. 2015 Nov 12;19:398. *========================================================================================= * Selected or ongoing grants/clinical studies *========================================================================================= AZV NU21J-06-00078 Skeletal muscle regeneration in survivors of critical illness: How to p cell failure?