prof. MUDr. František Duška, Ph.D. ****************************************************************************************** * ******************************************************************************************
Department of Anaesthesia and Intensive Care Medicine 3FM CU and UHKV https://www.lf3.cuni.cz/3LF-776.html [ URL "https://www.lf3.cuni.cz/3LF-776.html"] https://www.kar3lf.cz/en/research-2/ [ URL "https://www.kar3lf.cz/en/research-2/"] Topic title To be discussed individually. Could be in the field of bioenergetics and skeletal muscle w base physiology or gut microbiome and critical illness. *========================================================================================= * Description of scientific activity *========================================================================================= The Department of Anaesthesia and Intensive Care of Third Medical Faculty and FNKV Univers is a busy academic department of a tertiary teaching hospital, which provides perioperativ 18 000 patients a year and intensive care to over 1000 critically ill patients. Apart from to patients there is a strong research culture on our department. We do academic and indus randomized controlled trials, supported by 5 full time research nurses, and we ran two Eng labs nicknamed Oxylab (focused on muscle bioenergetics) and Carboxylab (focused on acid ba We are now opening new topic: investigating in a RCT faecal microbial transplantation for associated diarrhoea in the critically ill. Over the years we have built strong internatio and we currently prefer offering PhD studies on cotutelle, ie. on two universities at the ensures dedicated research time and facilitates funding. *========================================================================================= * Selected publications *========================================================================================= Waldauf P, Hrušková N, Blahutova B, Gojda J, Urban T, Krajčová A, Fric M, Jiroutková K, Řa F. Functional electrical stimulation-assisted cycle ergometry-based progressive mobility p mechanically ventilated patients: randomised controlled trial with 6 months follow-up. Tho Jul;76(7):664-671. doi: 10.1136/thoraxjnl-2020-215755. Epub 2021 Apr 30. PMID: 33931570; P (Example of an academic randomized controlled trial designed and conducted at our departme won nomination to the Prize of the Minister of Health) Dhanani S, Hornby L, van Beinum A, Scales NB, Hogue M, Baker A, Beed S, Boyd JG, Chandler D'Aragon F, Dezfulian C, Doig CJ, Duska F, Friedrich JO, Gardiner D, Gofton T, Harvey D, H G, Kramer AH, Kutsogiannis DJ, Maslove DM, Meade M, Mehta S, Munshi L, Norton L, Pagliarel Rusinova K, Scales D, Schmidt M, Seely A, Shahin J, Slessarev M, So D, Talbot H, van Mook P, Weiss M, Wind JT, Shemie SD; Canadian Critical Care Trials Group; Canadian Donation and Research Program. Resumption of Cardiac Activity after Withdrawal of Life-Sustaining Measu Med. 2021 Jan 28;384(4):345-352. doi: 10.1056/NEJMoa2022713. PMID: 33503343. (Example of collaborative project on physiology of dying appearing in prestigious New Engl Medicine) Krajčová A, L?vsletten NG, Waldauf P, Frič V, Elkalaf M, Urban T, Anděl M, Trnka J, Thores F. Effects of Propofol on Cellular Bioenergetics in Human Skeletal Muscle Cells. Crit Care Mar;46(3):e206-e212. doi: 10.1097/CCM.0000000000002875. PMID: 29240609. (Example of an in vitro study performed in Oxylab) *========================================================================================= * Selected or ongoing grants/clinical studies *========================================================================================= Oxylab: SATELLITE-1 Role of satellite cells in the development and outcomes of ICU acquire Carboxylab: Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in S ENTERPRISE (NCT03966664) Clinical: Effect of Two Different Doses of Dexamethasone in Patients With ARDS and COVID-1 NCT04663555) and many others *========================================================================================= * PhD Students *========================================================================================= Number of PhD students currently studying: 4 + 1 on cotutelle with University of Milan Number of defended students with year of defence: 5 (2015, 2016, 2018, 2019, 2021)