prof. MUDr. Tomáš Hájek, Ph.D. ****************************************************************************************** * ******************************************************************************************
National Institute of Mental Health, Klecany and Department of Psychiatry, Dalhousie Unive Scotia, Canada https://www.researchgate.net/profile/Tomas-Hajek-3 [ URL "https://www.researchgate.net/pro Hajek-3"] https://www.nudz.cz/ [ URL "https://www.nudz.cz/"] Topic title Brain imaging studies in bipolar disorders and schizophrenia *========================================================================================= * Description of scientific activity *========================================================================================= I received M.D. (1999) and Ph.D. in neuroscience (2003) from Charles University, Prague, t psychiatry and did a clinical research fellowship in mood disorders at Dalhousie Universit Canada. I am currently a professor of Psychiatry at Dalhousie University and Senior Resear Institute of Mental Health, Klecany. My research has focused on studying clinical variable brain changes in bipolar disorders (BD), including genetic risk, exposure to corticosteroi with Li, illness burden and most recently diabetes/prediabetes/obesity. The goal is to dif of the brain changes found in BD are primary, i.e. associated with genetic risk and which i.e. related to the presence of the illness, treatment or comorbid conditions. Whereas the could aid in early diagnosis, the secondary changes may perhaps be prevented. Through appl machine learning, we have also been testing the diagnostic use of magnetic resonance imagi in psychiatry. This effort has generated >115 publication, including manuscripts in top jo JAMA Psychiatry, Biological Psychiatry, Molecular Psychiatry, Neuropsychopharmacology, >43 h index of 33 according to Scopus. My research has attracted over CAD $5 million in resear established and lead the Neuroimaging research program at Dalhousie Department of Psychiat scanned over 400 participants for various studies. I have led several multisite internatio studies, with collaborators in Germany, Czech Republic, Austria, Poland. I am also a membe BD and ENIGMA-Schizophrenia Working groups. For more details, please see: https://publons.com/researcher/1199739/tomas-hajek [ URL "ht publons.com/researcher/1199739/tomas-hajek"] *========================================================================================= * Selected publications *========================================================================================= McWhinney S, Kolenic M, Franke K, Fialova M, Knytl P, Matejka M, Spaniel F, Hajek T. Obesi Factor for Accelerated Brain Ageing in First-Episode Psychosis-A Longitudinal Study. Schiz Oct 21;47(6):1772-1781. doi: 10.1093/schbul/sbab064. PMID: 34080013; PMCID: PMC8530396. McWhinney SR, Abé C, Alda M, Benedetti F, B?en E, Del Mar Bonnin C, Borgers T, Brosch K, C EJ, Cannon DM, Dannlowski U, Díaz-Zuluaga AM, Elvs?shagen T, Eyler LT, Fullerton JM, Goiko Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Landén M, Lemke H, Liberg B, Lopez-Jaramillo C, Malt UF, Martyn FM, Mazza E, McDonald C, M S, Meinert S, Meller T, Melloni EMT, Mitchell PB, Nabulsi L, Nenadic I, Opel N, Ophoff RA, JK, Pineda-Zapata JA, Pomarol-Clotet E, Radu? J, Repple J, Richter M, Ringwald KG, Roberts Savitz J, Schmitt S, Schofield PR, Sim K, Stein DJ, Stein F, Temmingh HS, Thiel K, van Har HV, Vargas C, Vieta E, Vreeker A, Waltemate L, Yatham LN, Ching CRK, Andreassen O, Thompso Association between body mass index and subcortical brain volumes in bipolar disorders-ENI individuals. Mol Psychiatry. 2021 Nov;26(11):6806-6819. doi: 10.1038/s41380-021-01098-x. E PMID: 33863996. Nunes A, Schnack HG, Ching CRK, Agartz I, Akudjedu TN, Alda M, Aln?s D, Alonso-Lana S, Bau B?en E, Bonnin CDM, Busatto GF, Canales- Rodríguez EJ, Cannon DM, Caseras X, Chaim-Avancin U, Díaz-Zuluaga AM, Dietsche B, Doan NT, Duchesnay E, Elvs?shagen T, Emden D, Eyler LT, Fa Favre P, Foley SF, Fullerton JM, Glahn DC, Goikolea JM, Grotegerd D, Hahn T, Henry C, Hiba J, Howells FM, Jahanshad N, Kaufmann T, Kenney J, Kircher TTJ, Krug A, Lagerberg TV, Lenro Jaramillo C, Machado-Vieira R, Malt UF, McDonald C, Mitchell PB, Mwangi B, Nabulsi L, Opel Pineda-Zapata JA, Pomarol-Clotet E, Redlich R, Roberts G, Rosa PG, Salvador R, Satterthwai JC, Stein DJ, Temmingh HS, Trappenberg T, Uhlmann A, van Haren NEM, Vieta E, Westlye LT, W D, Zanetti MV, Andreassen OA, Thompson PM, Hajek T. Using structural MRI to identify bipol 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Worki Psychiatry. 2020 Sep;25(9):2130-2143. doi: 10.1038/s41380-018-0228-9. Epub 2018 Aug 31. PM PMCID: PMC7473838. *========================================================================================= * Selected or ongoing grants/clinical studies *========================================================================================= Uher R, Alda M, Bowen C, Hajek T, Drobinin V (2021 - 2026). Brain development and the onse in youth [Grant] - CIHR - $1,400,000. Hajek T, Spaniel F (2020 - 2025). Obesity as a risk factor for adverse brain, cognitive an outcomes in schizophrenia - prospective study [Grant] - Health Research Agency of Czech Re $669,424. Hajek T, Calkin C, Uher R, Alda M (2015 - 2022). Is type 2 diabetes mellitus a risk factor neuroanatomical changes, cognitive impairment and oxidative stress in bipolar disorders? [ $864,220. Topic title and reference (to be filled in automatically after filling in the st *========================================================================================= * PhD Students *========================================================================================= Number of PhD students currently studying : 3 PhD, 3 MSc Number of defended students with year of defence: 3 PhD (2018, 2020, 2020)