doc. MUDr. Jan Trnka, Ph.D. ****************************************************************************************** * ******************************************************************************************
Laboratory for Metabolism and Bioenergetics Department of Biochemistry, Cellular and Molecular Biology https://www.lf3.cuni.cz/3LF-1059.html [ URL "https://www.lf3.cuni.cz/3LF-1059.html"] Topic title The interplay between ER-stress and mitochondrial stress in normal and cancer cells. *========================================================================================= * Description of scientific activity *========================================================================================= Jan completed studies in general medicine at the Third Faculty and continued to a PhD in b sciences at the University of Cambridge under the supervision of Professor Michael P. Murp focused on the biochemistry of mitochondria-targeted antioxidants and their interactions w complexes of the mitochondrial inner membrane. After returning to Prague he started buildi Laboratory for Metabolism and Bioenergetics to provide a basis for the study of cellular m mitochondrial biology. The current focus of his research team is cellular metabolism of de cancerous cells, impact of medications and other external chemicals on mitochondrial funct cooperation between cells. *========================================================================================= * Selected publications *========================================================================================= KFKOVÁ, Anežka; TRNKA, Jan. Mitochondria-targeted compounds in the treatment of cancer. Ne 67(3), 450-460. ISSN 0028-2685. e-ISSN 1338-4317. DOI: 10.4149/neo_2020_190725N671. VERLANDE, Amandine; KRAFČÍKOVÁ, Michaela; POTĚŠIL, David; TRANTÍREK, Lukáš; ZDRÁHAL, Zbyně Moustafa; TRNKA, Jan; SOUČEK, Karel; RAUCH, Nora; RAUCH, Jens; KOLCH, Walter; ULDRIJAN, St stress regulates ERK activity by controlling KSR-RAF heterodimerization. EMBO Reports. 201 320-336. ISSN 1469-221X. e-ISSN 1469-3178. DOI: 10.15252/embr.201744524 ELKALAF, Moustafa; TŮMA, Petr; WEISZENSTEIN, Martin; POLÁK, Jan; TRNKA, Jan. Mitochondrial Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydroge 2016, 11(8), e0161413. ISSN 1932-6203. e-ISSN 1932-6203. DOI: 10.1371/journal.pone.0161413 *========================================================================================= * PhD Students *========================================================================================= Current PhD students: 2 Completed PhD students: 2 (2015, 2017)