Archive of Topics

18 February 2016

Project:

Epistatic control of development of infectious disease


Mentor (Advisor):

Assoc. Prof. Marie Lipoldova, PhD.

Department:

Institute of Immunology/Institute of Molecular Genetics, AS CR

Contact information:

phone: +420 224310195

Project Narrative:

Epistasis plays an essential role in development of most diseases, but most interacting genes are unknown. We developed mouse model with a strong epistatic effect on susceptibility to leishmaniasis. Leishmania-susceptible B10.O20 mice carry 4% and 96% genes, respectively, of resistant strains O20 and C57BL/10. To define functional basis of this epistatic control we will map the O20 genes causing B10.O20 susceptibility and measure gene and pathway expression patterns in control and infected mice.

Requirements for student applicants:

M.Sc. degree or equivalent in genetics, molecular or cellular biology, parasitology, biomedicine, strong interest in basic research and experimental work, good English


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Third Faculty of Medicine

Charles University

Ruská 87, 100 00 Prague 10

Czech Republic


Phone.: +420 267 102 111


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