Project:

Metabolism of ovarian cancer tumors

Mentor (Advisor):

Assoc. Prof. RNDr. Petr Heneberg, Ph.D.; Ing. Daniela Šimčíková, Ph.D.

Department:

Department of Internal Medicine, Metabolism Reprogramming Lab

Contact information:

, 267 102 914

Web of the laboratory: https://www.lf3.cuni.cz/3LFEN-577.html

Project Narrative:

The project aims to elucidate the mechanisms by which a tumor cell overcomes nutrient deficiency during tumor progression and to find solutions allowing to prevent tumors from using alternative metabolic pathways. We use a model of high-grade serous ovarian cancer, which is still a difficult disease to treat. The project includes work on cell lines, isolates from patients and mouse xenografts and is based on the use of genetic and protein engineering approaches.

Requirements for student applicants:

We are looking for motivated and creative doctoral students interested in biomedical research, who would like to study the metabolism of tumor tissues using genetic and protein engineering tools (CRISPR/Cas9, CRISPRi), and biochemical and molecular biological methods. We expect enthusiasm and an active approach. The workplace is able to ensure an increase in regular scholarships and offers a part-time work contract. We offer a scientifically attractive topic under the guidance of experienced laboratory staff, support in career development, the opportunity to present the results at foreign conferences and carry out internships abroad.