doc. RNDr. Petr Heneberg, Ph.D. ****************************************************************************************** * ******************************************************************************************
Metabolism Reprogramming Lab Department of Internal Medicine 3FM CU and UHKV https://www.lf3.cuni.cz/3LFEN-577.html [ URL "https://www.lf3.cuni.cz/3LFEN-577.html"] Topic title Metabolism of ovarian cancer tumors [ URL "https://www.lf3.cuni.cz/3LFEN-729.html?news=117 *========================================================================================= * Description of scientific activity *========================================================================================= Petr graduated in Biology from Charles University in Prague. During his master and doctora specialized in mast cell submembrane signaling under the supervision of Petr Dráber at the Molecular Genetics AS CR. Afterwards, in 2008-2011, Petr held a postdoc position at the Di Cell and Developmental Biology of the Ontario Cancer Institute in Toronto, Canada, where h the role of protein tyrosine phosphatases in cancer onset and progression under the guidan G. Neel. After returning back to the Czech Republic, Petr established a laboratory affilia Third Faculty of Medicine (currently called the Metabolism Reprogramming Lab). The newly f focused on various aspects of metabolism, particularly on the effects of aberrant activity first on glucokinase diabetes, later on the roles of hexokinases in cancer. The recent top the research on the cancer-associated reprogramming of energetic metabolism in high grade carcinomas and clear cell renal carcinomas and the analysis of the same metabolic pathways healthy tissues. PI of several projects funded by GAČR, TAČR, AZV, IGA MZ ČR, etc.; member boards of Diabetes Care (2018-2020), PLoS ONE (since 2015) and Anti-Cancer Agents in Medic (since 2011); 169 papers in peer-reviewed journals, 2313 citations (WOS). *========================================================================================= * Selected publications *========================================================================================= Šimčíková, D.; Heneberg, P. Refinement of evolutionary medicine predictions based on clini the manifestations of Mendelian diseases. Scientific Reports, 2019, 9: 18577. Heneberg, P. Redox regulation of hexokinases. Antioxidants & Redox Signaling, 2019, 30, 41 Šimčíková, D.; Kocková, L.; Vackářová, K.; Těšínský, M.; Heneberg, P. Evidence-based tailo bioinformatics approaches to optimize methods that predict the effects of nonsynonymous am substitutions in glucokinase. Scientific Reports, 2017, 7: 9499. *========================================================================================= * Selected or ongoing grants/clinical studies *========================================================================================= Czech Science Foundation 15-03438Y (PI, 2015-2017): Mechanisms of the monogenic diabetes o and therapy Czech Science Foundation P301/12/1686 (PI, 2012-2014): Protein tyrosine phosphatases in re immune system of diabetic patients Czech Health Research Council 15-32432A (PI, 2015-2019): Preclinical applications of beauv cyclodepsipeptides of entomopathogenic fungi *========================================================================================= * PhD Students *========================================================================================= Number of PhD students currently studying : 0 Number of defended students with year of defence: 1 (2020)