Mgr. Lenka Rossmeislová, Ph.D.












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            Laboratory of Physiology and Pathophysiology of Adipose Tissue, Department of Pathophysiol
            https://www.lf3.cuni.cz/3LFEN-677.html [ URL "https://www.lf3.cuni.cz/3LFEN-677.html"]


            Topic title
            Interaction between adipose tissue and the lymphatic system [ URL "https://www.lf3.cuni.cz
            news=11736&locale=EN"]

            Characterization of adipose tissue properties affected by exercise




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            * Description of scientific activity
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            Lenka graduated in Molecular Biology, Virology and Genetics, her master thesis focused on 

            adipose tissue at the Institute of Physiology under the supervision of Dr. Jan Kopecký. In
            she worked as a research associate at the Pennington Biomedical Research Center, LSU, with
            Steven Smith, where she continued her research in adipose tissue in human in vivo and in v

            After returning to the Czech Republic, she joined Dr. Pavel Hozák at the Institute of Mole
            for her PhD studies, where she focused on various aspects of cellular aging with significa
            microscopy methods. She received her PhD degree in 2007, since then she has been working a

            of Medicine of Charles University, within the Department of Sport Medicine.  After the tra
            the Department, she became the head of the Laboratory of Physiology and Pathophysiology of
            in 2010. The laboratory is now involved in the study of various aspects of de novo lipogen

            tissue, including the synthesis of insulin-sensitizing PAHSA, adipose tissue-liver interac
            to starvation, as well as the study of lipolysis and secretory properties of adipose tissu
            with pancreatic cancer. Another research topic is the relationship between adipose tissue 

            system, i.e., addressing the question of how adipocytes affect lymphatic endothelial funct
            versa, how differently efficient lymphatic drainage affects the expansion of individual fa
            group is also the Czech half of the Czech-French Obesity Clinical Research Laboratory, und

            of Prof. Štich (3rd Faculty of Medicine) and Prof. Langin (INSERM). Lenka is/was a PI or c
            grants of the AZV and GAČR, is a partner in the H2020 project, publishes regularly, is a m
            panel of the AZV grant agency, reviews articles for many journals.





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            * Selected publications
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            KOC, M., WALD, M., VARALIOVA, Z., ONDRUJOVA, B., CIZKOVA, T., BRYCHTA, M., KRACMEROVA, J.,
            L., PALA, J., SRAMKOVA, V., SIKLOVA, M., GOJDA, J. & ROSSMEISLOVA, L. 2021. Lymphedema alt
            lipogenic, immune and angiogenic properties of adipose tissue: a hypothesis-generating stu

            cancer survivors. Sci Rep, 11, 8171.
            ČÍŽKOVÁ, T., ŠTĚPÁN, M., DAĎOVÁ, K., ONDRŮJOVÁ, B., SONTÁKOVÁ, L., KRAUZOVÁ, E., MATOUŠ, M
            GOJDA, J., KRAČMEROVÁ, J., ŠTICH, V., ROSSMEISLOVÁ, L. & ŠIKLOVÁ, M. 2020. Exercise traini

            inflammation of adipose tissue in the elderly: cross-sectional and randomized intervention
            Journal of Clinical Endocrinology & Metabolism.
            ROSSMEISLOVA, L., MALISOVA, L., KRACMEROVA, J., TENCEROVA, M., KOVACOVA, Z., KOC, M., SIKL

            M., VIQUERIE, N., LANGIN, D. & STICH, V. 2013. Weight loss improves the adipogenic capacit
            preadipocytes and modulates their secretory profile. Diabetes, 62, 1990-5.



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            * Selected or ongoing grants/clinical studies

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            2020-2026: TheraLymph –Gene Therapy to restore lymphatic flow lymphedema, H2020 SC1-BHC-07
            874708

            2021-2024: Novel approaches to enhance insulin-sensitizing effects of exercise: targeting 
            ETAPA; Czech Health Research Council project NU21-01-00469
            2019 - 2022: Pancreatic cancer: metabolic derangements assiocated with insulin resistence 

            Health Research Council project NV19-01-00101, Co-PI: Lenka Rossmeislova



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            * PhD Students
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            Number of PhD students currently studying : 2
            Number of defended students with year of defence: 3 PhD (2014,2015, 2017)