Project:

Molecular mechanisms of cancer cell resistance to chemotherapeutics

Mentor (Advisor):

Prof. RNDr. Jan Kovář, DrSs.

Department:

Department of biochemistry, cell and molecular biology

Contact information:

Tel: 267 102 658

Email:

Project Narrative::

Resistance of cancer cells to chemotherapeutics represents a crucial problem of the therapy of cancer diseases. We are dealing with molecular mechanisms of resistance and mechanisms of its development. We are interested in changes of expression of relevant genes in resistant cells, including changes concerning regulation of expression of these genes. Together with that we are dealing with possibilities to overcome resistance of cancer cells by relevant newly constructed chemotherapeutics.

Requirements for student applicants: