Team of prof. Romana Šlamberová, MD., Ph.D. from the Department of Physiology of the Third Faculty of Medicine, dealing with the consequences of drug exposure during pregnancy, were successful in publishing the work in a highly cited journal (quartile Q1) in the research of Physiology. The work is unique by comparing the effect of various perinatal factors on plasma oxytocin levels in juvenile offspring of drug-dependent laboratory rat mothers. The results of the work showed that both the long-term application of methamphetamine and the long-term exposure to stress due to the injection throughout the pregnancy affects the secretion of oxytocin in the pubertal age of the offspring. Thus, prenatal stress / drug is likely to affect significantly the hypothalamo- neurohypophyseal tract during fetal development. The results of the work emphasize the significant modulating role of long-term prenatal stress in the response of oxytocin to postnatal stressors as well as the direct single-dose administration of the drug in the pubertal age of an individual.
The work is supported by the PROGRES Q35 program, GACR 18-09296S project, GAUK 850317, PharmaBrain from OP VVV and 260388/SVV/2019 of Charles University.
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