• News


22 November 2022

New book “Voltage-Gated Calcium Channels”

Dr. Norbert Weiss, neuroscientist and electrophysiologist in the Department of Pathophysiology at the Third Faculty of Medicine, is the co-editor of a major book covering the molecular physiology and pathology of voltage-gated calcium channels in human disorders. 

This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing.  Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

Sdílet na:  

Third Faculty of Medicine

Charles University

Ruská 87, 100 00 Prague 10

Czech Republic

Phone.: +420 267 102 111

Fax: +420 267 311 812

Data Box ID: piyj9b4

ID No.: 00216208, VAT No.: CZ00216208

How to reach us

Your opinion