LIMOD - Laboratory for Integrative Metabolism and Oxygen Dynamics












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            The Laboratory for Integrative Metabolism and Oxygen Dynamics (LIMOD) investigates how met

            interact with oxygen availability, transport, and utilization under physiological conditio
            experimental models of hypoxia. The laboratory focuses on integrative mechanisms linking m
            dynamics, and tissue function across systemic, organ-level, and cellular responses, using 

            vivo and in vitro preclinical models.
            LIMOD employs a broad experimental platform, including indirect calorimetry, treadmill-bas
            exercise testing, cardiovascular and hemodynamic assessments, isolated organ perfusion, an

            microcirculatory analysis, combined with cellular and molecular approaches. These methods 
            evaluation of metabolic performance, exercise capacity, and endurance, as well as the unde

            of adaptation to altered oxygen availability.
            In addition to its research activities, LIMOD contributes to student education within the 
            of Pathophysiology 3FM CU, supporting teaching and training in experimental and integrativ

            sciences. The laboratory maintains close collaboration with several research groups, parti
            projects that integrate physiological, biochemical, and molecular methodologies. The overa
            to advance mechanistic understanding of disease processes and support the development of n

            strategies in metabolic disorders.

            Vedoucí: Moustafa Elekalaf, M.B.b.Ch., Ph.D.

            Email: moustafa.elkalaf@lf3.cuni.cz  [ URL "mailto:moustafa.elkalaf@lf3.cuni.cz"]

            Pracovníci:

            prof. MUDr. Jan Polák, Ph.D.
            MUDr. Kateřina Westlake, Ph.D.
            doc. Ing. Zdeněk Horák, Ph.D.


            Postgraduální studenti:
            Karolin Schulte

            Lucie Ryšková
            Filip Hušek
            Jan Hradil

            Tereza Báčová